In the middle of the twentieth century, the usefulness of psychedelics in the fight against mental illnesses, including depression, post-traumatic stress disorder, addiction and schizophrenia, began to be studied.

The pioneers of research on the use of these substances for medical purposes are Albert Hofmann (the discoverer of LSD) and Stanislav Grof (a Czech psychiatrist, co-founder of the Society for Transpersonal Psychology). Grof conducted LSD psychotherapy, which revealed hidden traumas, even as distant as birth-related trauma. The effect of the therapy itself caused a connection with psychoanalysis, but the therapeutic process progressed much faster. After the prohibition of LSD, Grof developed a method of holotropic breathing that allows one to achieve a different state of consciousness without using a psychedelic agent.

An interesting phenomenon related to the use of hallucinogens in therapy was the discovery of Howard Lotosof in 1962. At the age of 19, while addicted to heroin, he discovered the healing potential of ibogaine, a compound produced from the bark of an African plant. It was based mainly on a reduction in the withdrawal response after stopping drug and alcohol use. In addition to reducing withdrawal symptoms, the drug had a positive effect on the overall psychotherapeutic process, including, as later studies have shown, the treatment of depression.

It is also worth mentioning the experiments of Rick Strasman, who in 1990 (with the consent of the American Food and Drug Administration) I started checking how DMT affects the human body. Strassman became interested in this compound after discovering its endogenous nature. DMT was given to volunteers for 5 years, and the results of the experiments were described in a later book entitled DMT: The Soul Molecule. Some believe that the subjective experiences of the participants were distorted by the hospital conditions in which the tests were conducted, and the unpleasant visions were a response to the subject processing of the subjects by the staff.

In his book, Bohuslav Habrat argues that "addiction to hallucinogenic substances is rare, and some even dispute that it occurs at all." According to the author, most intoxications go away without the need for medical intervention, and only psychotic conditions may require hospitalization with sedatives.

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